Oslo Sports Trauma Research Center

Details about researcher: Rune B. Jakobsen

CV

Rune Jakobsen is an orthopedic surgeon at the Department of orthopedic surgery at Akershus University Hospital and associate professor at the Institute of Health and Society at the University of Oslo.

His main research interest is in cartilage biology, injury and treatment. Rune defended his PhD-thesis titled «Mesenchymal stem cells in cartilage repair - studies of chondrogenesis in vivo and in vitro» in 2014.

Rune has been a visiting researcher at the Harvard Stem Cell Institute and Broad Institute in Boston and at the Department of orthopedics at the University of Minnesota. He currently supervises candidates within the fields of cartilage biology and orthopedic trauma including projects on 3D-printing and teaches cell biology, orthopedic surgery, evidence-based medicine and quality improvement science to medical students.

Since 2020 he is project leader of the KLINBEFORSK-funded IMPROVE-ACL project which implements register-based randomisation into the Norwegian Knee Ligament Register.

Projects

• Improving the Treatment of Anterior Cruciate Ligament Tears in Norway – who should have surgery?

  Project manager: Caroline Kooy Tveiten

• Non-op. study

  Project manager: Caroline Kooy Tveiten

• Trends in pediatric ACL-reconstructions in Norway (2005-2019)

  Project manager: Caroline Kooy Tveiten

• Is there a negative effect on patient-reported outcomes in patients with concomitant cartilage lesions 12-15 years after ACL-reconstruction?

  Project manager: Katherine Wang

• Does new knowledge affect how patients with combined ACL-injuries and cartilage defects are treated?

  Project manager: Katherine Wang

• How valid are data from registries? An analysis of the compliance of clinical registries

  Project manager: Cathrine Nørstad Eftang, Katherine Wang

• An analysis of the quality of cartilage repair studies

  Project manager: Rune B. Jakobsen

• Cartilage injuries. The use of stem cells in joint resurfacing

  Project manager: Rune B. Jakobsen

Publications

• 2023

  • Major Increase in Incidence of Pediatric ACL Reconstructions From 2005 to 2021: A Study From the Norwegian Knee Ligament Register

    Kooy, Caroline E v. W; Jakobsen, Rune B.; Fenstad, Anne Marie; Persson, Andreas; Visnes, Håvard; Engebretsen, Lars; Ekås, Guri Ranum

    American Journal of Sports Medicine 2023 Sep;51(11):2891-2899

• 2021

  • Low-Input RNA-Sequencing in Patients with Cartilage Lesions, Osteoarthritis, and Healthy Cartilage

    Wang, Katherine; Esbensen, Q.Y; Karlsen, T.A; Eftang, Cathrine Nørstad; Owesen, Christian; Årøen, Asbjørn; Jakobsen, Rune Bruhn

    Cartilage. 2021 Nov 15th: Online ahead of print

  • Concomitant full-thickness cartilage lesions do not affect patient-reported outcomes at minimum 10-year follow-up after ACL reconstruction

    Wang, Katherine; Eftang, Cathrine Nørstad; Ulstein, Svend; Årøen, Asbjørn; Jakobsen, Rune Bruhn

    Knee Surgery, Sports Traumatology, Arthroscopy 2021 Oct 9;1-10 (Online ahead of print)

• 2020

  • Fixation of Acute Chondral Fractures in Adolescent Knees

    Kjennvold, Stian; Randsborg, Per-Henrik; Jakobsen, Rune B; Årøen, Asbjørn

    Cartilage 2020 July 16th [Online ahead of print]

  • Review of response rates over time in registry-based studies using patient-reported outcome measures

    Wang, Katherine; Eftang, Cathrine Nørstad; Jakobsen, Rune Bruhn; Årøen, Asbjørn

    British Journal of Sports Medicine 2020 August 6th [Online ahead of print]

• 2018

  • Compensation after treatment for anterior cruciate ligament injuries: a review of compensation claims in Norway from 2005 to 2015

    Randsborg, Per-Henrik; Bukholm, IRK; Jakobsen, Rune

    Knee Surg Sports Traumatol Arthrosc 2018:26(2):628-633

• 2014

  • Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling

    Jakobsen, Rune; Østrup, Esben; Zhang, Xiaolan; Mikkelsen, Tarjei S; Brinchmann, Jan E

    PLoS One:2014:9(5):):e96615

  • MicroRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN

    Karlsen, Tommy A; Jakobsen, Rune B; Mikkelsen, Tarjei S; Brinchmann, Jan E

    Stem Cells and Development 2014:23(3):290-304

• 2009

  • Chondrogenesis in a hyaluronic acid scaffold: comparison between chondrocytes and MSC from bone marrow and adipose tissue

    Jakobsen, Rune B; Shahdadfar, A; Reinholt, Finn P; Brinchmann, Jan E

    Knee Surgery, Sports Traumatology, Arthroscopy 2010:18(10):1407-1416

  • Clinical studies on posterior cruciate ligament tears have weak design

    Watsend, Anne Marie Eriksen; Osestad, Toril MØ; Jacobsen, Rune B; Engebretsen, Lars

    Knee Surgery, Sports Traumatology, Arthroscopy 2009:17(2):140-149

• 2008

  • The reproducibility and repeatability of varus stress radiographs in the assessment of isolated fibular collateral ligament and grade-III posterolateral knee injuries. An in vitro biomechanical study

    LaPrade, Robert; Heikes, Christie; Bakker, Adam J; Jakobsen, Rune B

    Journal of Bone and Joint Surgery. American volume 2008:90(10):2069-2076

  • Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model

    Løken, Sverre; Jakobsen, Rune B; Arøen, Asbjørn; Heir, Stig; Shahdadfar, Aboulghassem; Brinchmann, Jan E; Engebretsen, Lars; Reinholt, Finn P

    Knee Surgery, Sports Traumatology, Arthroscopy 2008:16(10):896-903

• 2007

  • An analysis of the quality of cartilage repair studies - an update

    Jakobsen, Rune; Engebretsen, Lars

    ISAKO Current Concepts 2007:1-4

• 2005

  • An analysis of the quality of cartilage repair studies

    Jakobsen, Rune; Engebretsen, Lars; Slauterbeck, James

    Journal of Bone and Joint Surgery – American Volume 2005:87(10):2232-2239